https://piche.org.pk/journal/index.php/jpiche/issue/feedJournal of the Pakistan Institute of Chemical Engineers2026-04-23T00:00:00+05:00Prof. Dr. Muhammad Arif Buttchief_editor.jpiche@piche.org.pkOpen Journal Systems<p>Journal of the Pakistan Institute of Chemical Engineers (JPIChE) is the publication of the Pakistan Institute of Chemical Engineers (PIChE). The journal has been approved by HEC. The Journal publishes articles covering wide range of fields of chemical and process engineering.</p>https://piche.org.pk/journal/index.php/jpiche/article/view/673Comprehensive chemical profiling and biological activities of Tinospora malabarica: Implications for herbal drug development and quality control2026-03-03T15:58:26+05:00Khadim Ali GishkoriKhadimaligishkori@gmail.comSaba Nazsaba.naz@usindh.edu.pkAftab Ahmed Kandhrochemist_afi@yahoo.com<p>This study investigates the chemical composition and biological activities of a significant medicinal plant species, Tinospora malabarica, Sindh region of Pakistan. Initially, the determination of physicochemical parameters was carried out to understand the general properties of plant. Phenolic compounds were identified using HPLC-PDA and 6 phenolics were detected in this species. Essential oils and volatile compounds were extracted through steam distillation. Analysis of each volatile constituent was done through GC-MS and 75 compounds were identified. Fatty acid profiling was conducted via GC-FID, and identified 19 fatty acids in T. malabarica. To evaluate the antioxidant capacity, BHT was used as control in DPPH assay. Antibacterial activity was evaluated by testing the extracts against five bacterial strains: Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhimurium, Staphylococcus aureus. The results provide a comprehensive understanding of this plant species' chemical composition and biological activities, highlighting its potential for the development of herbal drug formulations. Furthermore, the findings contribute to establishing quality control protocols for use of T. malabarica which is a raw materials used in herbal drug production.</p>2026-04-23T00:00:00+05:00Copyright (c) 2026 Journal of the Pakistan Institute of Chemical Engineers